General Notes
This product (Catalog No. DPABH-29066) is a rabbit-derived polyclonal antibody raised against human SIGMAR1, targeting the amino acid region 101–223 of the protein. This antibody exhibits cross-reactivity with Human SIGMAR1 from mouse, rat, and zebrafish. It has been affinity purified by Protein A. SIGMAR1, also named as OPRS1, SRBP, SIG-1R and AAG8, belongs to the ERG2 family. It is an endoplasmic reticulum chaperone that binds a wide variety of ligands, including neurosteroids, psychostimulants, and dextrobenzomorphans. SIGMAR1 is ubiquitously expressed, and is enriched in motor neurons of the brain and spinal cord. It plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. SIGMAR1 plays a role in several other cell functions including proliferation, survival and death. SDS-PAGE and Western blot analysis showed that SIGMAR1 has an apparent molecular mass of 28 kDa. SIGMAR1 has 5 isoforms with MW 21-27kDa and 12kDa.
DPABH-29066 is suitable for use in Western blot (WB) (1:1,000–1:8,000), IHC (1:250–1:1,000) applications.
DPABH-29066 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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