Anti-SHB (aa 67-95) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide within Mouse SHB aa 67-95 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: Q6PD21

Conjugate

Application Notes

WB: 1/1000.

Alternative Names

SHB; Src homology 2 domain containing adaptor protein B; SHB (Src homology 2 domain containing) adaptor protein B; SHB adaptor protein (a Src homology 2 protein); SH2 domain-containing adapter protein B; SHB adaptor protein (a Src homology 2 protein); SHB

Entrez Gene ID

UniProt ID

Antigen Description

Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.

Pathway

IL-2 Signaling Pathway; PDGFR-alpha signaling pathway; PDGFR-beta signaling pathway; Signaling events mediated by VEGFR1 and VEGFR2; T Cell Receptor Signaling Pathway;