A synthetic peptide of human SH3PXD2A is used for rabbit immunization.
Conjugate
Unconjugated
Target
Alternative Names
SH3PXD2A; SH3 and PX domains 2A; SH3 multiple domains 1 , SH3MD1; SH3 and PX domain-containing protein 2A; FISH; five SH3 domains; KIAA0418; adapter protein TKS5; adaptor protein TKS5; SH3 multiple domains 1; five SH3 domain-containing protein; tyrosine k
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.
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