Anti-SGCD monoclonal antibody, clone 4H20

Antibody Isotype

IgG1

Clone

4H20

Species Reactivity

Human

Immunogen

SGCD (NP_000328.2, 114 a.a. ~ 189 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

SGCD; sarcoglycan, delta (35kDa dystrophin-associated glycoprotein); sarcoglycan, delta (35kD dystrophin associated glycoprotein); delta-sarcoglycan; CMD1L; DAGD; LGMD2F; delta-SG; placental delta sarcoglycan; 35 kDa dystrophin-associated glycoprotein; dy

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.

Pathway

Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem; Hypertrophic cardiomyopathy (HCM), organism-specific biosystem; Hypertrophic cardiomyopathy (HCM), conserved biosystem; Viral myocarditis, organism-specific biosystem;