Anti-SF3B4 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human SF3B4 is used for rabbit immunization.

Conjugate

Alternative Names

SF3B4; splicing factor 3b, subunit 4, 49kDa; splicing factor 3b, subunit 4, 49kD; splicing factor 3B subunit 4; Hsh49; SAP49; SF3b49; SAP 49; SF3b50; spliceosomal protein; spliceosome-associated protein 49; spliceosome-associated protein (U2 snRNP); pre-m

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA.

Pathway

Gene Expression, organism-specific biosystem; Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem; Spliceosome, organism-specific biosystem; Spliceosome, conserved biosystem; Spliceosome, U2-snRNP, organism-specific biosystem; mRNA Splicing, organism-specific biosystem; mRNA Splicing - Major Pathway, organism-specific biosystem;