Recombinant fusion protein of human SETD8 (NP_065115.3).
Conjugate
Unconjugated
Applications
Application Notes
WB: 1:500-1:2000 IF: 1:50-1:100
General Notes
This product (Catalog No. DPABH-26122) is a rabbit-derived IgG polyclonal antibody raised against human SETD8. This antibody exhibits cross-reactivity with SETD8 from mouse and rat. It has been affinity purified by protein A. SETD8 (also known as KMT5A) is the sole methyltransferase in mammals responsible for catalyzing the monomethylation of histone H4 at lysine 20 (H4K20me1). It is crucial for cell cycle progression, DNA damage response (via 53BP1), and maintaining chromatin structure. Elevated SETD8 levels are linked to cancer, acting as an oncogene. DPABH-26122 is suitable for use in Western blot (WB) (1:500–1:2,000), IF (immunofluorescence) (1:50–1:100) applications. DPABH-26122 is supplied as a liquid formulation in PBS with 0.02% sodium azide, 50% glycerol, pH7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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