Anti-SETD1B (aa 685-720) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse

Immunogen

Synthetic peptide within Human KMT2G/ hSET1B aa 685-720 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: Q9UPS6

Conjugate

Application Notes

WB: 1/100 - 1/500;

Alternative Names

SETD1B; SET domain containing 1B; KMT2G; Set1B; histone-lysine N-methyltransferase SETD1B; hSET1B; lysine N-methyltransferase 2G; SET domain-containing protein 1B;

Entrez Gene ID

UniProt ID

Antigen Description

Histone methyltransferase that specifically methylates Lys-4 of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring Lys-9 residue is already methylated. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates Lys-4 of histone H3 in vitro.

Pathway

Lysine degradation;