Anti-SEPP1 monoclonal antibody, clone 38B2

Antibody Isotype

IgG1

Clone

38B2

Species Reactivity

Human

Immunogen

Selenoprotein-P protein purified from Human plasma

Conjugate

Alternative Names

SEPP1; selenoprotein P, plasma, 1; selenoprotein P; SeP; SELP;

Entrez Gene ID

UniProt ID

Antigen Description

Selenoprotein-P(SelP) is the major selenoprotein in human blood plasma and a transport protein which is carrying selenium to various extrahepatic tissues. Though its expression is detected in most tissues, highest amounts are produced by the liver, which secretes highly glycosylated SelP into plasma. Purification of human SelP yields two distinct isoforms with 61 and 55 kDa, differing in selenium content. SelP also has been shown to chelate heavy metals such as cadmium and mercury, and there are several evidences about its serum antioxidant capacity and protection against oxidative stress. Selenium deficiency predispose to several pathological condition such as cancer, coronary heart disease and liver necrosis although the biological function of SelP in various pathologic conditions has not been established.

Pathway

Integrin-mediated cell adhesion, organism-specific biosystem; Selenium Metabolism and Selenoproteins, organism-specific biosystem; Selenium Pathway, organism-specific biosystem;