Anti-SENP5 (aa 2-109) polyclonal antibody

Species Reactivity

Human

Immunogen

SENP5 (NP_689912, 2 a.a. ~ 109 a.a) partial recombinant protein with GST tag. The sequence is KKQRKILWRKGIHLAFSEKWNTGFGGFKKFYFHQHLCILKAKLGRPVTWNRQLRHFQGRK KALQIQKTWIKDEHLCAKTKFNVATQNVSTLSSKVKRKDAKHFISSSK

Conjugate

Alternative Names

SENP5; SUMO1/sentrin specific peptidase 5; sentrin-specific protease 5; SUMO1/sentrin specific protease 5; sentrin/SUMO-specific protease SENP5;

Entrez Gene ID

UniProt ID

Antigen Description

The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]

Pathway

Metabolism of proteins; Processing and activation of SUMO; SUMOylation;