Sterol-C4-mehtyl oxidase-like protein was isolated based on its similarity to the yeast ERG25 protein. It contains a set of putative metal binding motifs with similarity to that seen in a family of membrane desaturases-hydroxylases. The protein is localized to the endoplasmic reticulum membrane and is believed to function in cholesterol biosynthesis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Pathway
Cholesterol biosynthesis; Cholesterol biosynthesis, squalene 2,3-epoxide cholesterol; Metabolism; Metabolism of lipids and lipoproteins; Steroid biosynthesis; cholesterol biosynthesis I; cholesterol biosynthesis II (via 24,25-dihydrolanosterol); cholesterol biosynthesis III (via desmosterol); superpathway of cholesterol biosynthesis; zymosterol biosynthesis.
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