Anti-SATB2 polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide conjugated to KLH derived from within residues 700 to the C-terminus of Mouse SATB2.

Conjugate

Application Notes

WB: 1 μg/ml.

Alternative Names

SATB2; special AT-rich sequence binding protein 2; DNA-binding protein SATB2; KIAA1034-like DNA binding protein; special AT-rich sequence-binding protein 2; two cut domains-containing homeodomain protein; mKIAA1034;

Entrez Gene ID

UniProt ID

Antigen Description

Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.

Pathway

PluriNetWork;