Anti-SARS2 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human SARS2 is used for rabbit immunization.

Conjugate

Alternative Names

SARS2; seryl-tRNA synthetase 2, mitochondrial; SARSM, serine tRNA ligase, mitochondrial , seryl tRNA synthetase 2; serine--tRNA ligase, mitochondrial; FLJ20450; mtSerRS; SARS; serine tRNA ligase 2; mitochondrial; SerRSmt; SERS; SYS; seryl-tRNA(Ser/Sec) sy

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene.

Pathway

Aminoacyl-tRNA biosynthesis, organism-specific biosystem; Aminoacyl-tRNA biosynthesis, conserved biosystem; Aminoacyl-tRNA biosynthesis, eukaryotes, organism-specific biosystem; Aminoacyl-tRNA biosynthesis, eukaryotes, conserved biosystem; Gene Expression, organism-specific biosystem; Mitochondrial tRNA aminoacylation, organism-specific biosystem; Selenium Metabolism and Selenoproteins, organism-specific biosystem.