Recombinant protein corresponding to amino acids of recombinant SALL3. The sequence is AYDDKNAETLSSYDDDMDENSMEDDAELKDAATDPAKPLLSYAGSCPPSPPSVISSIAAL ENQMKMIDSVMSCQQLTGLKSVENGSGE
Conjugate
Unconjugated
Applications
Application Notes
IF: 1-4 μg/mL; IHC: 1:200-1:500. & The optimal working dilution should be determined by the end user.
Target
Alternative Names
SALL3; spalt-like transcription factor 3; ZNF796; sal-like protein 3; hSALL3; zinc finger protein 796; C2H2 zinc finger protein SALL3; spalt-like zinc finger protein;
This gene encodes a sal-like C2H2-type zinc-finger protein, and belongs to a family of evolutionarily conserved genes found in species as diverse as Drosophila, C. elegans, and vertebrates. Mutations in some of these genes are associated with congenital disorders in human, suggesting their importance in embryonic development. This protein binds to DNA methyltransferase 3 alpha (DNMT3A), and reduces DNMT3A-mediated CpG island methylation. It is suggested that silencing of this gene, resulting in acceleration of DNA methylation, may have a role in oncogenesis.
Citations
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