Synthetic peptide: C-RRKQRKELSHYT, corresponding to internal sequence amino acids 915-926 of Human Robo3 (NP_071765.2).
Conjugate
Unconjugated
Applications
Application Notes
Peptide ELISA: Antibody detection limit dilution 1/32000. WB: Use at a concentration of 0.5 - 1 μg/ml. Detects a band of approximately 148 kDa (predicted molecular weight: 148 kDa).
Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube. In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1 (By similarity). Required for hindbrain axon midline crossing.
Pathway
Axon guidance; Developmental Biology; Regulation of Commissural axon pathfinding by Slit and Robo; Signaling by Robo receptor;
Citations
Publication ()
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