General Notes
This product (Catalog No. DPABH-19785) is a rabbit-derived polyclonal antibody raised against human RanBP1, targeting the amino acid region 1–60 of the protein. This antibody exhibits cross-reactivity with Human RanBP1 from mouse. It has been affinity purified by Protein A. RanBP1 (Ran-binding protein 1) belongs to the RANBP1 family. RanBP1 plays a role in RAN-dependent nucleocytoplasmic transport. It alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus. And RanBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PMID:20485264). RanBP1 promotes dissociation of RAN from a complex with KPNA2 and CSE1L. It required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (PMID:17671426). Also, RanBP1 inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (PMID:7882974, PMID:7616957).
DPABH-19785 is suitable for use in Western blot (WB) (1:1,000–1:6,000), IHC (1:400–1:1,600), IF/ICC (1:50–1:500) applications.
DPABH-19785 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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