Anti-RAB27A (full length) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Rat

Immunogen

Purified recombinant full length rat rab 27A.

Conjugate

Alternative Names

RAB27A; RAB27A, member RAS oncogene family; ras-related protein Rab-27A; ashen; ash; 2210402C08Rik; 2410003M20Rik; 4933437C11Rik;

Entrez Gene ID

UniProt ID

Antigen Description

Rab 27 proteins are members of the Rab protein family that belongs to the ras-related superfamily of small monomeric GTPases. These proteins are involved in intracellular fusion reactions of vesicles or organelles with their target membranes. Two Rab 27 isoforms, Rab 27A and 27B, have been described so far. Mutations in the Rab 27A gene have been shown to be responsible for the Griscelli syndrome characterized by pigment dilution of the hair and an uncontrolled T-lymphocyte and macrophage activation. This disorder is probably due to the dysfunction of melanosomes in melanocytes and lytic granules in CTLs. Additionally Rab 27A is located on mature insulin granules of pancreatic Beta-cells and is expressed in the pigment epithelium and choriocapillaris of the retina. In patients who suffer from Griscelli syndrome because of missense mutations in the Rab 27A gene, Rab 27B is upregulated and partially compensates for Rab 27A dysfunction. Rab 27B also regulates amylase secretion in parotid acinar cells. Recently it has been shown that Rab 27 is also involved in synaptic transmission in C. elegans.

Pathway

Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; Insulin Synthesis and Processing, organism-specific biosystem; cyclic AMP biosynthesis, organism-specific biosystem;