Anti-RTN4 monoclonal antibody, clone FQS23376

Antibody Isotype

IgG

Clone

FQS23376

Species Reactivity

Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human Nogo aa 100-200 (Cysteine residue). The exact sequence is proprietary.Database link: Q9NQC3

Conjugate

Application Notes

WB: 1/1000 - 1/10000; ICC/IF: 1/100 - 1/250; IP: 1/10 - 1/100; Flow Cyt: 1/10 - 1/100; IHC-P: 1/50 - 1/100.

Alternative Names

RTN4; reticulon 4; reticulon-4; ASY; KIAA0886; NOGO; NSP CL; foocen; Human NogoA; reticulon 5; My043 protein; neurite outgrowth inhibitor; neurite growth inhibitor 220; neuroendocrine-specific protein C homolog; NSP; NOGOC; RTN-X; NOGO-A; NSP-CL; Nogo-B;

Entrez Gene ID

UniProt ID

Antigen Description

Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.

Pathway

Axonal growth inhibition (RHOA activation), organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signalling by NGF, organism-specific biosystem; p75 NTR receptor-mediated signalling, organism-specific biosystem; p75(NTR)-mediated signaling, organism-specific biosystem; p75NTR regulates axonogenesis, organism-specific biosystem;