Synthetic peptide: QHPSAKGNLCPPT, corresponding to internal sequence amino acids 181-193 of Human RSPO3 (NP_116173.2). RSPO3
Conjugate
Unconjugated
Applications
Application Notes
WB: 0.3 - 1 μg/ml.
Target
Alternative Names
RSPO3; R-spondin 3; R spondin 3 homolog (Xenopus laevis); thrombospondin, type I, domain containing 2; THSD2; R-spondin-3; FLJ14440; R-spondin 3 homolog; roof plate-specific spondin-3; protein with TSP type-1 repeat; thrombospondin, type I, domain contain
Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway.
Citations
Publication ()
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