General Notes
This product (Catalog No. DPABH-01556) is a rabbit-derived polyclonal antibody raised against human RRN3, targeting the amino acid region 268–365 of the protein. This antibody exhibits cross-reactivity with Human RRN3 from mouse. It has been affinity purified by Protein A. RRN3, also known as transcription initiation factor IA, is a key regulatory protein essential for RNA polymerase I-mediated ribosomal DNA transcription. It functions as a bridge molecule that precisely regulates the recruitment of RNA polymerase I to the rDNA promoter and the assembly of the transcription initiation complex by integrating intra- and extracellular signals (such as growth factors, nutrient status, and cellular stress). The activity of RRN3 is tightly controlled by multiple signaling pathways. Specifically, the mTOR and MAPK pathways can activate RRN3 through phosphorylation, thereby promoting ribosomal RNA synthesis and ultimately influencing cell growth and proliferation. Studies have shown that RRN3 is abnormally highly expressed in various cancer cells and is closely associated with malignant tumor progression, making it a potential therapeutic target for anticancer strategies.
DPABH-01556 is suitable for use in Western blot (WB) (1:1,000–1:4,000), IP (0.5-4.0 μg for 1.0-3.0 mg of total protein lysate), IHC (1:250–1:1,000) applications.
DPABH-01556 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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