Specifications
Immunogen
Synthetic peptide, corresponding to N terminal amino acids of Human p53R2 (UniProt: Q7LG56).
Applications
Application Notes
WB: 1/1000 - 1/10000; IHC-P: 1/50 - 1/100; ICC/IF: 1/250 - 1/500; IP: 1/10 - 1/100; Flow Cyt: 1/10 - 1/100;
Target
Alternative Names
RRM2B; ribonucleotide reductase M2 B (TP53 inducible); ribonucleoside-diphosphate reductase subunit M2 B; p53R2; TP53-inducible ribonucleotide reductase M2 B; p53-inducible ribonucleotide reductase small subunit 2 homolog; p53-inducible ribonucleotide red
Product Background
Antigen Description
Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.
Pathway
Direct p53 effectors, organism-specific biosystem; Glutathione metabolism, organism-specific biosystem; Glutathione metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem; Nucleotide Metabolism, organism-specific biosystem;
Citations
Publication ()
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COA
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