Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
Pathway
Activated TLR4 signalling; Axon guidance; CREB phosphorylation through the activation of Ras; Cellular responses to stress
Citations
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