RPRM (reprimo, TP53 dependent G2 arrest mediator candidate) is a protein-coding gene. Diseases associated with RPRM include pancreatic ductal adenocarcinoma, and gastric cancer, and among its related super-pathways are DNA damage response. An important paralog of this gene is RPRML. May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity).
Pathway
p53 signaling pathway;
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