Anti-RPL8 monoclonal antibody, clone FQS22741

Antibody Isotype

IgG

Clone

FQS22741

Species Reactivity

Mouse; Rat; Human

Immunogen

Recombinant fragment corresponding to Human RPL8.

Conjugate

Application Notes

WB: 1/10000 - 1/50000; ICC/IF: 1/250 - 1/500; IP: 1/10 - 1/100;

Alternative Names

RPL8; ribosomal protein L8; 60S ribosomal protein L8; L8;

Entrez Gene ID

UniProt ID

Antigen Description

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Pathway

Cap-dependent Translation Initiation, organism-specific biosystem; Cytoplasmic Ribosomal Proteins, organism-specific biosystem; Disease, organism-specific biosystem; Eukaryotic Translation Elongation, organism-specific biosystem; Eukaryotic Translation Initiation, organism-specific biosystem; Eukaryotic Translation Termination, organism-specific biosystem; Formation of a pool of free 4S subunits, organism-specific biosystem.