Anti-RPA4 (full length) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant full length protein corresponding to Human RPA4 aa 1-261.Sequence: MSKSGFGSYGSISAADGASGGSDQLCERDATPAIKTQRPKVRIQDVVPCN VNQLLSSTVFDPVFKVRGIIVSQVSIVGVIRGAEKASNHICYKIDDMTAK PIEARQWFGREKVKQVTPLSVGVYVKVFGILKCPTGTKSLEVLKIHVLED MNEFTVHILETVNAHMMLDKARR

Conjugate

Application Notes

WB: 1 μg/ml; IHC-P: 3 μg/ml; ICC/IF: 10 μg/ml.

Alternative Names

RPA4; replication protein A4, 30kDa; replication protein A4, 34kDa; replication protein A 30 kDa subunit; HSU24186; RP-A p30; RF-A protein 4; replication factor A protein 4; replication protein A complex 34 kd subunit homolog Rpa4; MGC120333; MGC120334;

Entrez Gene ID

UniProt ID

Antigen Description

Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.

Pathway

Activation of the pre-replicative complex; Cell Cycle; Cell Cycle, Mitotic; DNA Replication; DNA Replication Pre-Initiation; DNA replication;