RNF41 contains one RING-type zinc finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. It acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins, such as ERBB3. RNF41 has been detected in ovary, testis and prostate.
Pathway
Adaptive Immune System; Antigen processing: Ubiquitination & Proteasome degradation; Class I MHC mediated antigen processing & presentation; Downregulation of ERRB2:ERBB3 signaling; Endocytosis
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Wang, L; Pan, X; et al. Vps41, a protein involved in lysosomal trafficking, interacts with caspase-8. ACTA BIOCHIMICA POLONICA 60:37-42(2013).
Wauman, J; De Ceuninck, L; et al. RNF41 (Nrdp1) controls type 1 cytokine receptor degradation and ectodomain shedding. JOURNAL OF CELL SCIENCE 124:921-932(2011).
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COA
Certificate of Analysis