Anti-RNF216 polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide within Human TRIAD3 aa 775-825 (C terminal). The exact sequence is proprietary.Sequence: VEKVQRVEALPRPVPQ NLPQPQMPPY AFAHPPFPLPPVRPVFNNFPLNMGP Database link: Q9NWF9

Conjugate

Unconjugated

Application Notes

IP: 2-10 μg/mg lysate.

Alternative Names

RNF216; ring finger protein 216; ZIN; CAHH; U7I1; TRIAD3; UBCE7IP1; E3 ubiquitin-protein ligase RNF216; triad domain-containing protein 3; zinc finger protein inhibiting NF-kappa-B; ubiquitin-conjugating enzyme 7-interacting protein 1;

Entrez Gene ID

54476

UniProt ID

A8K8N1

Antigen Description

The TRIAD3 gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known.

Pathway

Gastric cancer network 1;

We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More