This product (Catalog No. DPABH-11621) is a rabbit-derived polyclonal antibody raised against human RNF208. This antibody exhibits cross-reactivity with RNF208 from mouse. It has been affinity purified by Protein A. RNF208 (Ring Finger Protein 208) is an estrogen-inducible E3 ubiquitin ligase that acts as a tumor suppressor by promoting the polyubiquitination and proteasomal degradation of soluble Vimentin. It is particularly recognized for suppressing metastasis in triple-negative breast cancer (TNBC) by inhibiting the migration and invasion of cancer cells. DPABH-11621 is suitable for use in IHC (1:50–1:100) application. DPABH-11621 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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