Specifications
Immunogen
RNF168 antibody was raised against an 18 amino acid peptide from near the carboxy terminus of human RNF168.
Target
Alternative Names
RNF168; ring finger protein 168, E3 ubiquitin protein ligase; hRNF168; E3 ubiquitin-protein ligase RNF168
Product Background
Antigen Description
This gene encodes an E3 ubiquitin ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in DNA double-strand break (DSB) repair. Mutations in this gene result in Riddle syndrome. [provided by RefSeq, Sep 2011]
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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Citations
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Sharma, N; Zhu, QZ; et al. USP3 counteracts RNF168 via deubiquitinating H2A and gamma H2AX at lysine 13 and 15. CELL CYCLE 13:106-114(2014).
Ramachandran, S; Chahwan, R; et al. The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107:809-814(2010).
COA
Certificate of Analysis
