Anti-RNF139 (C-terminal) polyclonal antibody

Species Reactivity

Human

Immunogen

A synthetic peptide corresponding to C-terminus of human RNF139. The sequence is C-HTGAAAEEFNDDT

Conjugate

Application Notes

ELISA: 1:16000; WB: 0.3-1 μg/mL; IHC-P: 3-4 μg/mL. & The optimal working dilution should be determined by the end user.

Alternative Names

RNF139; ring finger protein 139; RCA1; TRC8; HRCA1; E3 ubiquitin-protein ligase RNF139; multiple membrane spanning receptor TRC8; patched related protein translocated in renal cancer; translocation in renal carcinoma on chromosome 8 protein;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.

Pathway

SREBP signalling;