Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production.
Pathway
Immune System; Innate Immune System; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Negative regulators of RIG-I/MDA5 signaling; RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways; TRAF3-dependent IRF activation pathway;
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