Anti-RNF128 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat; Human

Immunogen

A synthetic peptide of human RNF128 is used for rabbit immunization.

Conjugate

Alternative Names

RNF128; ring finger protein 128, E3 ubiquitin protein ligase; ring finger protein 128; E3 ubiquitin-protein ligase RNF128; FLJ23516; GRAIL; gene related to anergy in lymphocytes protein;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Pathway

Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem;