Anti-RNF11 monoclonal antibody

Antibody Isotype

IgG

Clone

FQS7931

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to residues near the C terminus of Human RNF11 (UniProt Q9Y3C5).

Conjugate

Unconjugated

Application Notes

WB: 1/1000 - 1/10000; IHC-P: 1/50 - 1/100; IP: 1/10 - 1/100; Flow Cyt: 1/100 - 1/500;

Alternative Names

RNF11; ring finger protein 11; RING finger protein 11; CGI 123; MGC51169; Sid1669p; CGI-123; SID1669;

Entrez Gene ID

26994

UniProt ID

Q9Y3C5

Antigen Description

Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates Lys-63 polyubiquitin chains on RIPK1 and catalyzes the formation of Lys-48-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.

We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More