Rabbit Anti-Human RNASEH2B (a.a. 1-331) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse; Rat

Immunogen

Recombinant human RNASEH2B protein; Source: E. coli derived, PGEX-4T; Tag: GST; Domain: 1-331 aa of BC036744

Conjugate

Application Notes

WB: 1:500-1:1000

General Notes

This product (Catalog No. DPABH-20926) is a rabbit-derived polyclonal antibody raised against human RNASEH2B, targeting the amino acid region 1–331 of the protein. This antibody exhibits cross-reactivity with Human RNASEH2B from mouse and rat. It has been affinity purified by Protein A. Ribonuclease H2 is the major nuclear enzyme degrading cellular RNA/DNA hybrids in eukaryotes and the sole nuclease known to be able to hydrolyze ribonucleotides misincorporated during genomic replication. RNASEH2B and RNASEH2C are the non-catalytic subunits of RNase H2 complex. Defects in RNASEH2B are a cause of Aicardi-Goutieres syndrome type 2 (AGS2), a genetically heterogeneous disease with clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process.
DPABH-20926 is suitable for use in Western blot (WB) (1:500–1:1,000) application.
DPABH-20926 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

AGS2; DLEU8; Ribonuclease H2 subunit B; ribonuclease H2; subunit B; Ribonuclease HI subunit B; RNase H2 subunit B; RNASEH2B

Entrez Gene ID

UniProt ID