Anti-RMI2 (aa 99-146) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

antigen sequence: GKYVMVMGVV QACSPEPCLQ AVKMTDLSDN PIHESMWELE VEDLHRNI, corresponding to amino acids 99-146 of Human RMI2.

Conjugate

Application Notes

ICC/IF: 1 - 4 μg/ml. WB: 1/250 - 1/500. IHC-P: 1/200 - 1/500.

Alternative Names

RMI2; RecQ mediated genome instability 2; BLAP18; C16orf75; recQ-mediated genome instability protein 2; hRMI2; BLM-associated protein of 18 kDa; RMI2, RecQ mediated genome instability 2, homolog; RecQ-mediated genome instability 2, S. cerevisiae, homolog

Entrez Gene ID

UniProt ID

Antigen Description

Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. The complex is therefore essential for the stability, localization, and function of complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM.

Pathway

Blooms syndrome complex; Fanconi anemia pathway;