Anti-RLIM (full length) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Full length protein corresponding to Human RNF12 aa 1-624. (NP_057204.2).Sequence: MENSDSNDKGSGDQSAAQRRSQMDRLDREEAFYQFVNNLSEEDYRLMRDN NLLGTPGESTEEELLRRLQQIKEGPPPQNSDENRGGDSSDDVSNGDSIID WLNSVRQTGNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQ NSENENEPSARRSSGENVE

Conjugate

Application Notes

WB: 1 μg/ml;

Alternative Names

RLIM; ring finger protein, LIM domain interacting; RNF12; NY-REN-43; E3 ubiquitin-protein ligase RLIM; R-LIM; ring finger protein 12; E3 ubiquitin-protein ligase RNF12; renal carcinoma antigen NY-REN-43; RING finger LIM domain-binding protein; ring zinc f

Entrez Gene ID

UniProt ID

Antigen Description

E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.