Anti-RIN2 (aa 786-894) polyclonal antibody

Species Reactivity

Human

Immunogen

RIN2 (NP_061866, 786 a.a. ~ 894 a.a) partial recombinant protein with GST tag. The sequence is DFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQ QLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTT

Conjugate

Alternative Names

RIN2; Ras and Rab interactor 2; MACS; RASSF4; ras and Rab interactor 2; RAS inhibitor JC265; RAB5 interacting protein 2; RAS association domain family 4; RAS interaction/interference protein 2; RAS association (RalGDS/AF-6) domain containing protein JC265

Entrez Gene ID

UniProt ID

Antigen Description

The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. The protein encoded by this gene binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family. Mutations in this gene cause macrocephaly alopecia cutis laxa and scoliosis (MACS) syndrome, an elastic tissue disorder, as well as the related connective tissue disorder, RIN2 syndrome. Alternative splicing results in multiple transcript variants.

Pathway

Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met).