General Notes
This product (Catalog No. DPABH-08391) is a rabbit-derived polyclonal antibody raised against human RIC8B, targeting the amino acid region 145–495 of the protein. This antibody exhibits cross-reactivity with Human RIC8B from mouse and rat. It has been affinity purified by Protein A. Ric8, also known as synembryn, is a guanine nucleotide exchange factor (GEF) that enhances variegated G protein signaling pathways, including Gα(q) and Gα(s) regulation of neurotransmission, Gα(i)-dependent mitotic spindle positioning during (asymmetric) cell division, and Gα(olf)-dependent odorant receptor signaling (PMID: 21467038). In mammals, two Ric8 homologues have been reported (Ric8A and Ric8B). Ric8B is able to potentiate G(s)/G(olf) signaling (PMID: 15829631; 16754875; 20133939).
DPABH-08391 is suitable for use in Western blot (WB) (1:2,000–1:12,000), IHC (1:20–1:200), IF/ICC (1:200–1:800) applications.
DPABH-08391 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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