Anti-RHOC (aa 91-190) polyclonal antibody

Species Reactivity

Human

Immunogen

RHOC (NP_786886, 91 a.a. ~ 190 a.a) partial recombinant protein with GST tag. The sequence is SLENIPEKWTPEVKHFCPNVPIILVGNKKDLRQDEHTRRELAKMKQEPVRSEEGRDMANR ISAFGYLECSAKTKEGVREVFEMATRAGLQVRKNKRRRGC

Conjugate

Alternative Names

RHOC; ras homolog family member C; H9; ARH9; ARHC; RHOH9; rho-related GTP-binding protein RhoC; rhoC GTPase; oncogene RHO H9; rho cDNA clone 9; RAS-related homolog 9; small GTP binding protein RhoC; ras homolog gene family, member C;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Pathway

Axon guidance; G alpha (12/13) signalling events; Rho GTPase cycle; Sema4D induced cell migration and growth-cone collapse.