Anti-RGS17 (aa 111-210) polyclonal antibody

Species Reactivity

Human

Immunogen

RGS17 (NP_036551, 111 a.a. ~ 210 a.a) partial recombinant protein with GST tag. The sequence is LLFWLACEDLKKEQNKKVIEEKARMIYEDYISILSPKEVSLDSRVREVINRNLLDPNPHM YEDAQLQIYTLMHRDSFPRFLNSQIYKSFVESTAGSSSES

Conjugate

Alternative Names

RGS17; regulator of G-protein signaling 17; RGSZ2; RGS-17; hRGS17;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.

Pathway

Calcium Regulation in the Cardiac Cell; GPCR downstream signaling; Signal Transduction;