Specifications
Species Reactivity
Mouse; Rat; Dog; Human; Monkey
Immunogen
Recombinant full length Human RFC4 produced in HEK293T cells (NP_002907).
Applications
Application Notes
WB: 1/200 - 1/4000; IHC-P: 1/150; ICC/IF: 1/100;
Target
Alternative Names
RFC4; replication factor C (activator 1) 4, 37kDa; replication factor C (activator 1) 4 (37kD); replication factor C subunit 4; A1; A1 37 kDa subunit; activator 1 37 kDa subunit; RFC 37 kDa subunit; RFC37; RF-C 37 kDa subunit; activator 1 subunit 4; repli
Product Background
Antigen Description
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template.
Pathway
Activation of ATR in response to replication stress, organism-specific biosystem; BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle Checkpoints, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Chromosome Maintenance, organism-specific biosystem; DNA Repair, organism-specific biosystem.
Citations
Publication ()
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COA
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