Anti-RFC1 (aa 400-700) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant fragment corresponding to Human RFC1 aa 400-700.Sequence: PKGAENCLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLV MGRDSGQSKSDKAAALGTKIIDEDGLLNLIRTMPGKKSKYEIAVETEMKK ESKLERTPQKNVQGKRKISPSKKESESKKSRPTSKRDSLAKTIKKETDVF WKSLDFKEQVAEETSGDSKARNLADDSSENKV

Conjugate

Application Notes

IHC-P: 1/50 - 1/200; WB: 1/500 - 1/2000.

Alternative Names

RFC1; replication factor C (activator 1) 1, 145kDa; replication factor C (activator 1) 1 (145kD); replication factor C subunit 1; A1; MHCBFB; PO GA; RFC140; A1 140 kDa subunit; RF-C 140 kDa subunit; activator 1 subunit 1; replication factor C1; MHC bindin

Entrez Gene ID

UniProt ID

Antigen Description

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA.Interacts with C-terminus of PCNA. 5 phosphate residue is required for binding of the N-terminal DNA-binding domain to duplex DNA, suggesting a role in recognition of non-primer template DNA structures during replication and/or repair.

Pathway

BRCA1-associated genome surveillance complex (BASC); Cell Cycle; Cell Cycle, Mitotic; Chromosome Maintenance; DNA Repair; DNA Replication;