Anti-REST polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Human

Immunogen

Synthetic peptide conjugated to KLH derived from within residues 1050 to the C-terminus of Mouse REST/ NRSF.

Conjugate

Application Notes

WB: 1μg/ml;

Alternative Names

REST; RE1-silencing transcription factor; NRSF; AA407358; 2610008J04Rik; neural-restrictive silencer factor;

Entrez Gene ID

UniProt ID

Antigen Description

Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.

Pathway

Huntingtons disease; PluriNetWork;