General Notes
This product (Catalog No. DPABH-11381) is a rabbit-derived polyclonal antibody raised against human RDH13, targeting the amino acid region 1–260 of the protein. It has been affinity purified by Protein A. Retinol dehydrogenase 13 (RDH13) is a protein-coding gene in humans, located on the long arm of chromosome 19 at position 19q13.42, that encodes a mitochondrial enzyme belonging to the short-chain dehydrogenase/reductase (SDR) family. This enzyme primarily functions as a retinaldehyde reductase, efficiently converting all-trans-retinaldehyde to all-trans-retinol using NADPH as a cofactor, while also exhibiting weaker activity in oxidizing retinol to retinaldehyde. RDH13 is thought to safeguard mitochondria from oxidative stress by metabolizing retinoids at the inner mitochondrial membrane. Expressed across human tissues with low specificity, RDH13 shows highest RNA levels in the retina and brain regions such as the hippocampus and cerebral cortex, and highest protein levels in the retina. It is also expressed in embryonic tissues. The protein localizes to the inner mitochondrial membrane. Research has highlighted RDH13's protective effects, such as mitigating acute light-induced damage in the mouse retina through its dehydrogenase activity, and reducing liver fibrosis in models of carbon tetrachloride toxicity by modulating genes like Spot14 and Cyp2e1. While no direct human disease associations have been firmly established, variants in RDH13 have been noted in genetic databases, and its interactions with proteins like polyglutamine-expanded ataxin-3 suggest potential relevance to neurodegenerative processes involving mitochondrial dysfunction.
DPABH-11381 is suitable for use in Western blot (WB) (1:1,000–1:4,000) application.
DPABH-11381 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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