Anti-RCOR1 monoclonal antibody, clone FQS24936

Antibody Isotype

IgG

Clone

FQS24936

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human CoREST aa 1-100. The exact sequence is proprietary.Database link: Q9UKL0

Conjugate

Application Notes

WB: 1/10000 - 1/50000; IHC-P: 1/50; ICC/IF: 1/100;

Alternative Names

RCOR1; REST corepressor 1; RCOR, REST corepressor; COREST; KIAA0071; RCOR;

Entrez Gene ID

UniProt ID

Antigen Description

Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome.

Pathway

Factors involved in megakaryocyte development and platelet production, organism-specific biosystem; Hemostasis, organism-specific biosystem; Huntingtons disease, organism-specific biosystem; Huntingtons disease, conserved biosystem;