General Notes
This product (Catalog No. DPABH-04617) is a rabbit-derived polyclonal antibody raised against human RBM22, targeting the amino acid region 1–420 of the protein. This antibody exhibits cross-reactivity with Human RBM22 from mouse and rat. It has been affinity purified by Protein A. RBM22 is mainly involved in pre-mRNA splicing, playing the essential role of maintaining the conformation of the catalytic core of the spliceosome and acting as a bridge between the catalytic core and other essential protein components of the spliceosome. RBM22 is also involved in gene regulation, and is able to bind DNA, acting as a bona fide transcription factor on a large number of target genes. Due to its wide scope in the regulation of gene expression, RBM22 has been associated with several pathologies and, notably, with the aggressiveness of cancer cells and with the phenotype of a myelodysplastic syndrome. (PMID: 35158909).
DPABH-04617 is suitable for use in Western blot (WB) (1:2,000–1:10,000), IHC (1:250–1:1,000), IF/ICC (1:50–1:500) applications.
DPABH-04617 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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