Anti-RASGRP2 (aa 14-42) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide within Human RASGRP2 aa 14-42 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: Q7LDG7

Conjugate

Application Notes

WB: 1/100 - 1/500; IHC-P: 1/10 - 1/50; ICC/IF: 1/10 - 1/50.

Alternative Names

RASGRP2; RAS guanyl releasing protein 2 (calcium and DAG-regulated); RAS guanyl-releasing protein 2; CALDAG GEFI; hCDC25L; cdc25-like protein; F25B3.3 kinase-like protein; guanine exchange factor MCG7; RAS guanyl nucleotide-releasing protein 2; calcium an

Entrez Gene ID

UniProt ID

Antigen Description

Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.

Pathway

Adaptive Immune System; Chemokine signaling pathway; Effects of PIP2 hydrolysis; G alpha (q) signalling events; GPCR downstream signaling; Hemostasis;