Anti-RASD2 monoclonal antibody (DCABH-558)

Mouse anti-Human RASD2 monoclonal antibody for WB, FC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
2H2
Species Reactivity
Dog, Human
Immunogen
Recombinant full length Human RASD2 protein (NP_055125).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/500 - 1/2000; Flow Cyt: 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
RASD2; RASD family, member 2; GTP-binding protein Rhes; MGC:4834; Ras homolog enriched in striatum; Rhes
Entrez Gene ID
UniProt ID

Product Background


Gene summary
RASD2 (RASD Family Member 2) is a Protein Coding gene. Diseases associated with RASD2 include huntington disease. GO annotations related to this gene include GTP binding and ubiquitin conjugating enzyme binding. An important paralog of this gene is RAP2B. This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients.
Antigen Description
GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination. GTP-binding protein Rhes is a protein that in humans is encoded by the RASD2 gene. 0The function about RASD2 antigen include G-protein beta-subunit binding; GTP binding; GTPase activity; nucleotide binding; phosphatidylinositol 3-kinase binding; ubiquitin conjugating enzyme binding.

Citations


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References


Gromova, P; Ralea, S; et al. Kit K641E oncogene up-regulates Sprouty homolog 4 and Trophoblast glycoprotein in interstitial cells of Cajal in a murine model of gastrointestinal stromal tumours. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 13:1536-1548(2009).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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