Anti-RARB monoclonal antibody, clone 447

Name: Anti-RARB monoclonal antibody, clone 447
SKU: DCABY-870
Rating: 5 (1 reviews)

Mouse anti-Human RARB monoclonal antibody for WB

COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgG1

Clone

447

Species Reactivity

Human; Rat

Conjugate

Unconjugated

Applications

Application Notes

WB: 1:1000

Target

Alternative Names

Retinoic acid receptor beta; RAR-beta; HBV-activated protein; Nuclear receptor subfamily 1 group B member 2; RAR-epsilon; RARB; HAP; NR1B2

Entrez Gene ID

5915

UniProt ID

F1D8S6

Product Background

Antigen Description

Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X receptors (RXRs) family (RXRα, β and γ) preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors (RARs). RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.

Pathway

Gene Expression; Generic Transcription Pathway; Integrated Pancreatic Cancer Pathway; Non-small cell lung cancer; Nuclear Receptor transcription pathway; Nuclear Receptors; Nuclear receptors in lipid metabolism and toxicity; Pathways in cancer;

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

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References

HHIP, HDAC4, NCR3 and RARB polymorphisms affect fetal, childhood and adult lung function

EUROPEAN RESPIRATORY JOURNAL

Authors: Collins, Samuel A.; Lucas, Jane S. A.; Inskip, Hazel M.; Godfrey, Keith M.; Roberts, Graham; Holloway, John W.

Abstract

Aberrant methylation of tumor suppressor genes in patients with refractory anemia with ring sideroblasts

LEUKEMIA RESEARCH

Authors: Valencia, Ana; Cervera, Jose; Such, Esperanza; Ibanez, Mariam; Gomez, Ines; Luna, Irene; Senent, Leonor; Oltra, Silvestre; Sanz, Miguel A.; Sanz, Guillermo F.

Abstract

This study evaluates the incidence and prognostic impact of aberrant methylation of 25 tumor suppressor genes in 40 patients with RARS, a MDS subtype, by methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) assay. Methylation of at least one gene was detected in 18 patients (45%). The genes methylated were CDKN2B (20%), RASSF1 (18%), RARB (10%), CDH13 (7.5%) and FHIT (5%). Patients with at least one methylated gene had a significantly shorter OS than patients without methylated genes. Aberrant methylation is a frequent event in patients with RARS as in patients with high-risk MDS appears to confer a worse prognosis. (c) 2010 Elsevier Ltd. All rights reserved.