Specifications
Species Reactivity
Mouse; Rat; Dog; Human; Monkey
Immunogen
Recombinant full length protein corresponding to Human GRF2 aa 1-1095. Produced in HEK293T cells.Sequence: MGNAIEKQKPLKRSHLYPWKQDSQRSHLSSFTMKLMDKFHSPKIKRTPSK KGKPAEVSVKIPEKPVNKEATDRFLPEGYPLPLDLEQQAVEFMSTSAVAS RSQRQKNLSWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSA
Applications
Application Notes
WB: 1/400 - 1/4000; IHC-P: 1/150; ICC/IF: 1/100;
Target
Alternative Names
RAPGEF1; Rap guanine nucleotide exchange factor (GEF) 1; GRF2, guanine nucleotide releasing factor 2 (specific for crk proto oncogene); rap guanine nucleotide exchange factor 1; C3G; CRK SH3-binding GNRP; guanine nucleotide-releasing factor 2 (specific f
Product Background
Antigen Description
Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS.
Pathway
ARMS-mediated activation, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Downstream signal transduction, organism-specific biosystem; E-cadherin signaling in the nascent adherens junction, organism-specific biosystem; EPO signaling pathway, organism-specific biosystem; Focal Adhesion, organism-specific biosystem.
Citations
Publication ()
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COA
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