Anti-RAP1GAP2 polyclonal antibody (DPABH-17694)

Rabbit anti-Human RAP1GAP2 (aa 700-730) polyclonal antibody for WB, IHC-P Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Mouse, Human
Immunogen
Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 700-730 of Human RAP1GAP2
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/100 - 1/500; IHC-P: 1/50 - 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
RAP1GAP2; RAP1 GTPase activating protein 2; GARNL4; RAP1GA3; rap1 GTPase-activating protein 2; GTPase activating RANGAP domain-like 4
Entrez Gene ID
UniProt ID

Product Background


Gene summary
RAP1GAP2 (RAP1 GTPase Activating Protein 2) is a Protein Coding gene. Among its related pathways are Immune System and Rap1 signalling. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RAP1GAP. This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene.
Antigen Description
RAP1GAP2 is a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. In vitro phosphorylated by cGMP-dependent protein kinase 1 (cGKI) at Ser-7; the phosphorylation probably does not regulate GAP activity. There are 3 isoforms produced by alternative splicing. Isoform 1 and isoform 2 are expressed in platelets with isoform 2 being the predominant form. GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. The function about RAP1GAP2 antigen include GTPase activator activity.
Pathway
Adaptive Immune System; Rap1 signalling.

Citations


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References


Gegenbauer, K; Nagy, Z; et al. Cyclic Nucleotide Dependent Dephosphorylation of Regulator of G-Protein Signaling 18 in Human Platelets. PLOS ONE 8:-(2013).

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